Features of cytokine balance with the progression of structural changes in the gastric mucosa in patients with atrophic gastritis

Background. Until now, the issue of correlation between cytokine balance and progression structural changes in gastric mucosa remain completely uncertain. At same time, determination role as a component carcinogenesis will make it possible to substantiate new approaches managing patients with atrophic gastritis. The purpose was assess level pro- anti-inflammatory cytokines, vascular endothelial growth factor (VEGF) at stages Materials methods. study included 79 individuals gastritis who underwent narrow band imaging endoscopic examination. were divided into groups taking account revealed mucosa: group I— 7 people mucosal atrophy without intestinal metaplasia (IM); II— 16 IM limited by antrum; III— 45 diffuse against background atrophy; IV— 10 dysplasia. In all patients, we assessed interleukins (IL-8, IL-10, IL-18), tumor necrosis alpha (TNF-α), VEGF. Results. IV, concentration IL-8 blood serum 18.6 (11.3; 23.9) pg/ml that significantly higher than I (by 5.0 times, p<0.05), II 3.6 p<0.05) III 3.4 p<0.05). According results Kruskal-Wallis test, probability difference 0.0260. VEGF dysplasia increased compared 1.8 those 1.7times, Changes towards proinflammatory cytokines most pronounced IV; according IL-8/IL-10 ratio 0.0207. Conclusions. With gastritis, an increase IL-18 TNF-α) does not induce secretion (IL-10). ROC analysis, diagnostic criteria for formation risk detecting dysplastic are more 341.4 mU/ml (sensitivity— 90.0%, specificity— 77.2%) above 14.4 80.0%, 78.3%).